Sandrino (Richard Gutierrez), Magnus' son, also known as Supremo, orders his forces to hunt the Rodriguez family to prevent the prophecy's fulfillment and ensure his ascendancy into power.

[3][4] Supremo kills Mateo and Lia, unaware that the 7-year-old Malia is carried off to safety at a secret LLU base in Tanay, Rizal[5] by the werewolf Baristo (Joross Gamboa).

A few remnants find each other in Manila, where Malia meets Tristan (Daniel Padilla), a young man seeking to avenge his father's death by vampires.

Tristan joins a secret youth vigilante group called Moonchasers, who track and kill vampires and protect Supremo's targeted victims.

Four characters precipitate Malia's evolution from mortal to supernatural: There is Supremo, a lonely boy raised by an evil vampire who confers on him the enchantment of the cursed ink.

At the enchanted forest scene, Jacintha chooses not to kill Sandrino, pointing to the cursed ink as the real evil, foreshadowing her true mission.

Jacintha is the political strategist who Gilbert Imperial hires to run his presidential campaign, a vampire and Hybrid secretly working with Samantha to undermine Supremo while they wait for Malia's full powers to emerge.

Barang's memories lead Jacintha to the enchanted forest where she retrieves the ancient book of spells and learns how to defeat the curse: a beating heart and the First Werewolf's Fang.

Angry over the tragic circumstances that turn him into a vampire, memories flood Tristan's mind: his fallen comrades, the family he lost and all humans caught in the crossfire of the power struggle between the supernaturals.

As Supremo plans their return, Tristan has a different agenda - create a war that annihilates vampires and werewolves and yield the world to humans only.

Although Malia prefers the supernaturals to not participate, she is overruled by her council members who do not take her concerns about the threat of a new war seriously, dismissing her fears as irrelevant.

Certain that Jacintha defeated the cursed ink, the black werewolves plan to take over the predatory might to feed on humans, violating their decades-long vow to protect them.

Colluding with Supremo, President Osmundo's military forces systematically round up the werewolves and are tortured and killed in undisclosed facilities.

At the Heroes Ball, the LLU witnesses Tristan and Malia working from opposite forces, protecting the humans from a mass conversion and not a single vampire survives.

The first major encounter does not end well for Tristan, Malia and the LLU, the biggest blow being the loss of all the Moonchasers except for Prof T and Hanno.

After convincing him to abandon his revenge to destroy all the supernaturals with his acid red rain, Malia and Tristan bid goodbye to Prof T and erase his memories of their time together.

Amidst the grief and loss suffered, Malia's full transformation occurs, becoming a red-caped hybrid werewolf with vampiric characteristics and powers similar to Jacintha.

But just as Supremo prepares to deliver the final blow, the couple link hands and a surge of energy flows between them just as seen in Jethro's prophecy.

In the epilogue, Malia notes that hardships will always be part of life even though the threat of the curse ink is now gone as long as there are mortals, werewolves, and vampires that have ill intentions.

Portrayed by Kathryn Bernardo (adult) and Erika Clemente (child), the main female character of the series, she is the New Chosen One who defeats the evil vampire marked with the cursed ink, hybrid offspring of Mateo and Lia, and Supremo's enemy.

Tristan secretly protects humans from increasing vampire attacks and plans to annihilate the supernatural species but is conflicted about Malia's fate because he loves her.

Tristan's path is foreshadowed early in the series when his stepfather Tonio advises the six-year-old that his real battle would be waged in his heart.

Tristan takes the ultimate risk to face Supremo, hoping to appeal to any remaining piece of humanity Sandrino felt towards his brother, to end the apocalypse.

When the Lunas capture Rica and kill Sandrino, Barang invokes the spell of the Cursed Ink, conferring upon him a protection from all weapons and transforms him into a vampire.

He assumes the leadership of his race and becomes the Supremo, the King of evil vampires and architect of a utopian world without werewolves where humans exist solely as their food source.

On the night of the blood moon, she uses the First Werewolf's fang to end the cursed ink inside Sandrino, stripping him of his invincibility and weakening him.

La Luna Sangre marks the return of the KathNiel love team (consisting of Kathryn Bernardo and Daniel Padilla) to television after last starring in the 2015 series, Pangako sa 'Yo.

Since May 15, 2017, ABS-CBN has started uploading all the episodes of Lobo and Imortal on the network's YouTube channel, as prior to the premiere of La Luna Sangre.

On October 4, 2017, iWant TV exclusively expands La Luna Sangre universe with a "Youtopia" web series which centers on a group of friends whose friendships and trust in each other are tested, as they cross paths with the vampires of Sandrino's army.

It premiered from January 28, 2008 to July 11, 2008 replacing Patayin sa Sindak si Barbara on ABS-CBN's Primetime Bida evening block and worldwide on The Filipino Channel.