The song was released for digital download and streaming by La Industria, Inc. and Sony Music Latin on October 8, 2020, as the second single from the album.

A Spanish language reggaeton song, it is about a young unmarried woman, whose mysterious and flirtatious manner drives men crazy.

Then the team decided to include Tainy to contribute to the production and finally, as Turizo "felt that a strong contrasting voice was missing", Rauw Alejandro joined the recording.

[3] Musically, "La Nota" is a Spanish language reggaeton song,[4][5] written by Juan Medina, Turizo, Towers, Michael Torres, and Alejandro.

[2] Lyrically, "La Nota" which translates to "The Note" in English, is a sensual song about a young unmarried woman, whose "flirtatious and mysterious" manner "drive[s] men crazy".

[5] The lyrics include, "Sin hablar tú y yo nos entendemos / Ambos sabemos lo que sigue / Y aprovecha que nos conocemos / Colaboremos pa' que se dé / Que la nota le suba pa’ que mueva su cintura" (Without speaking, you and I understand each other / We both know what's next / And take advantage of the fact that we know each other / Let's collaborate so that it happens / Let the grade go up so that you move your waist).

[5][10] In 2022, Ernesto Lechner from Rolling Stone ranked the track as Alejandro's 42nd-best song, naming the singer as the one who "steals the spotlight" in the collaboration, "adding tension and adrenaline to a hit that would remain middle of the road if not for the fiery inspiration of his verses".

[18] "La Nota" debuted at number 11 on the US Billboard Hot Latin Songs chart on October 24, 2020,[19] becoming Turizo's 17th entry, Alejandro's 9th, and Towers' 19th.

[28] "La Nota" also peaked at number one in Chile,[29] Colombia,[30] Ecuador,[31] and Mexico,[32] and reached the top 10 in Bolivia,[33] Costa Rica,[34] Dominican Republic,[35] El Salvador,[36] Guatemala,[37] Latin America,[38] Panama,[39] Peru,[40] Puerto Rico,[41] and Uruguay.

[7] Turizo, Alejandro, and Towers gave their first live performance of "La Nota" at the 27th Annual Billboard Latin Music Awards on October 21, 2020.