He emigrated from Mexico to San Antonio, Texas, in 1908, where Lozano first founded a Spanish-language daily newspaper known as La Prensa in 1913.

With the increase in the Mexican population Los Angeles experienced during the 1920s, Lozano believed he had a strong base for a Spanish newspaper in the growing city and founded La Opinión on September 16 to coincide with Mexico's Independence Day.

In its early existence La Opinión consisted primarily of news from Mexico to accommodate the reading preferences of its audience, made up in large part by recently emigrated Mexicans.

"[10] Since 1986, La Opinión's editorial staff has doubled in size and the paper has grown to include bureaus in Sacramento, California, Washington, D.C., and Mexico City.

In 1999 and 2000, La Opinión was recognized by the National Association of Hispanic Journalists as the Outstanding Spanish Language Daily Newspaper of the Year.

In 2006, La Opinión received the highest-ranking recognition in Spanish-language journalism, the José Ortega y Gasset Award from Spain’s El País newspaper.

El País honored La Opinión for its pioneering trajectory over eighty years creating and maintaining an unprecedented media outlet for the growing Hispanic population in the United States.