La Plata station is an Amtrak train station in La Plata, Missouri, United States and is a timetabled passenger stop for Amtrak's Southwest Chief long-distance route between Chicago and Los Angeles.

It was built in 1945 by the Atchison, Topeka and Santa Fe Railway as a replacement for an 1887-built, 1888-opened passenger and freight depot that was in deteriorating condition.

Efforts to replace the station were stalled by a lack of construction material during World War II.

The 1945 replacement was built in Art Deco style, and was restored between 1996 and 2001 by local preservationists, a model railroad club, and a garden club.

This Missouri train station-related article is a stub.