[2] La Prensa was then founded by José and Antonio Dutriz, and its first issue was printed and distributed on May 10, 1915.

Antonio retired in 1928 due to illness[4] and José Dutriz remained as sole owner.

[4] During Quetglas' term as director, the newspaper had to deal with the issue of censorship under the government of General Maximiliano Hernández Martínez.

[4] A book published in 2002, titled "José Dutriz y el diario ‘La Prensa'" relates the history of the newspaper and its founder.

Television chain Univisión and La Prensa forged an alliance in 2004 to foster the exchange of information.