[1][2] After four years in prison in the United States for the deaths of three DEA agents, Teresa Mendoza escapes but will have to face a world full of conspiracy, risking her life in order to clear her name and reunite with her daughter Sofía.

On 16 July 2020, Telemundo announced that it had renewed La Reina del Sur for a third season.

[4] The season was filmed for seven months in countries like Bolivia, Peru, Argentina and Colombia.

[11] La Reina del Sur: 3ra Temporada (Banda Sonora Original) is the soundtrack to the third season of the series.

[74][75] It features 45 score cues composed by Carlos Rafael Rivera, and the theme song of the third season performed by The Miami Symphony Orchestra and Sofi Saar.