Lawrence Manuel, FSC was the longest serving principal of La Salle Higher Secondary School, Multan, i.e. from 1986 to 2007.

The principal of the school said that Christian educational institutions have contributed a lot in nurturing the country's leadership.

[1] The school's most prominent alumnus is Yousaf Raza Gilani, ex-prime minister of Pakistan.

[2] Brother Emmanuel Nicholas who taught Gilani in the 1960s, was reunited with his student during a South Asian Association for Regional Cooperation meeting in Colombo in March 2008.

The following individuals have served as principal of La Salle Higher Secondary School, Multan: