La Seine Musicale was inaugurated on 22 April 2017 with a concert by Insula orchestra [fr], accompanied by the Accentus choir, conducted by Laurence Equilbey at the Patrick Devedjian Auditorium.

[1] During inauguration week a day earlier, American folk rock singer Bob Dylan was the first recording artist to hold a concert at the venue, for which he chose to perform at the 6,000-seat Grand Seine.

[4] In July 2009, the lead coordinating architect for the project was named as Jean Nouvel;[5] although individual buildings have subsequently been commissioned from a range of international architectural practices.

The initial complex of buildings on the island opened in April 2017 and were designed by the architectural team of Shigeru Ban and Jean de Gastines [fr].

Much of the site's daytime energy needs are supplied by a large mobile curved solar panel array that covers the smaller auditorium.