Link Crew was a system implemented in 2005 that was aimed at helping incoming freshman students acclimate to the high school environment by having junior and senior peer mentors help them through their first year in the Whittier Union High School District.

In 2006, English teacher Holly Vance was demoted from her position as the adviser of the newspaper's production,[9] due to the controversial[10] penultimate issue on May 10, 2006, entitled "The 'S' Word", which discussed sex amongst teenagers.

La Serna High School's yearbook is called The Pennon, which is created by the Annual Staff (students) and a teacher adviser.

Their sports include football, track and field, cross country, soccer, volleyball, baseball, softball, tennis, wrestling, swimming, basketball and Marching Band.

The 1990 La Serna Baseball team were the CIF 3A Champions led by Coach Vern Brock, beating Tustin 1-0.

In 2019, the Boys' Cross Country Program reached the CIF State Meet for the first time in school history, finishing 12th overall at the Division I level.