It serves students in grades 9–12 in the cities of Santa Fe Springs, Norwalk, Downey, and Whittier.

Sports offered include wrestling, football, basketball, baseball, track, soccer, tennis, water polo, swimming, softball, volleyball, cross-country, cheerleading and golf.

[5] Santa Fe High School also offers many clubs and sports and activities.

One of the many clubs available is FBLA (Future Business Leaders of America) which students from Santa Fe High school have partaken in and placed nationally in business competitions.

Another club is Santa Fe's ASB (Associated Student Body) which has won the California Student Activities Best Activities Program award (sponsored by CADA and CASL) for ten consecutive years.