[1] La Settimana Enigmistica was founded by Giorgio Sisini, a Milan-based Sardinian nobleman, Count of Sant'Andrea.

The first edition of the magazine was published on 23 January 1932 and featured a stylized portrait of Mexican actress Lupe Vélez on the front cover.

The magazine has featured word puzzles contributed by the most famous constructors, including Piero Bartezzaghi, Giancarlo Brighenti, Bruno Makain and Sisini himself.

One characteristic that makes La Settimana Enigmistica unique is that it does not accept advertising and rarely uses it to sell the magazine.

As well as crosswords, the magazine contains many other types of puzzle, including: Every week there is at least one competition open to readers, with a special annual one in December.