The program began broadcasting on 4 August 2008 at 4 pm on the Nine Network with hosts Drew Jarvis[2] and Nicole Dixon.
On 5 March 2012, the show moved to the Seven Network with Aleisha Rose replacing Dixon for the revived series.
In contrast to other Australian children's game shows such as Sharky's Friends, A*mazing, and Go Go Stop, which are filmed on a large set in front of a live studio audience, Lab Rats Challenge uses several smaller sets resembling an abandoned science laboratory as well as special effects sequences inserted in post-production.
The challenges on the show are born from science experiments,[4] such as guessing how many drops of water will fit on a twenty cent coin.
Both teams pour their powder in the water and the one that has a chemical reaction wins 5 points.