Lac qui Parle Mission is a pre-territorial mission in Chippewa County, Minnesota, United States, which was founded in June 1835 by Dr. Thomas Smith Williamson and Alexander Huggins after fur trader Joseph Renville invited missionaries to the area.

[2][3] "Lac qui Parle" is the French translation of the native Dakota name, "Mde Lyedan," meaning "lake which speaks".

[2] Renville was related to and had many friends in the Native community, and after his death in 1846, the mission was taken over by the "irreligious" Martin McLeod.

The relationship between the mission and the Dakota people worsened, and in 1854 the missionaries abandoned the site and relocated to the Upper Sioux Agency.

[6] Located a half mile from the mission site,[3] the fort was a significant outpost in southwestern Minnesota, and was a stopping point for traders on the Red River Trails.