[3][4] Generally, Lactuca canadensis is a biennial herb in the daisy family growing from a taproot to maximum heights of 50–200 cm (19.5–78.5 in) or more.

The top of the stem bears an inflorescence with many flower heads, each up to 1 cm (0.5 in) wide when open.

The fruit is a dark-colored achene about half a centimeter (0.2 inches) long with a white pappus.

Leaf surface color ranges from shiny to dull in light to dark green pigments that sometimes may appear in purple or yellow shear cast.

Leaves are slightly toothed along margins with small hairs along underside of leaf vein.

Lactuca canadensis can be found in woodlands, thickets, savannas, borders of lakes and rivers, limestone glades, fence rows, pastures, abandoned fields, powerline clearances, road and railroad sides, vacant lots, and waste areas.

[6] Lactuca canadensis contains lactucarium, which is the milky sap (white latex) that flows through the stem, leaves, and roots of the plant.

A survivalist publication, The Lost Ways, states that its fresh leaves may be used to create a solution that may act as an analgesic and may be stored for later use.

It may be used as medicinal treatments for its anodyne, antispasmodic, digestive, diuretic, hypnotic, narcotic, and sedative properties.

[6] Cultivation preferably is in moist to slightly dry conditions and in full to partial sun.