He then, addressing himself particularly to me, as the person least likely to be acquainted with the character of Mr. Beauclerk, drew it himself in strong and marked expressions, describing the misery he gave his wife, his singular ill-treatment of her, and the necessary relief the death of such a man must give.
She painted portraits, illustrated plays and books, provided designs for Wedgwood's innovative pottery, and decorated rooms with murals.
Championed by her close friend Horace Walpole, whose letters illuminate all aspects of her life, she was able to establish herself as an admired artist at a time when women struggled to forge careers.
Beauclerk illustrated a number of literary productions, including Horace Walpole's tragedy The Mysterious Mother, the English translation of Gottfried August Bürger's Leonora (1796) and The Fables of John Dryden (1797).
After 1785 she was one of a circle of women, along with Emma Crewe and Elizabeth Templetown (1746/7-1823), whose designs for Josiah Wedgwood were made into bas-reliefs on jasper ornaments.
Beauclerk designed the allegorical group, sculpted by John de Veere of the Coade Stone factory, to decorate the plain facade of the Pelican and British Empire Life Insurance Company at 70 Lombard Street in the City of London.
In the mid-1990s a portrait of her hung in Kenwood House, Hampstead in north London, with the caption: "Lady Diana Spencer, known chiefly for the unhappiness of her first marriage."