She first appeared in Lloyd's Register (LR) in 1808 with Gander, master, Gouch & Co., owners, and trade London transport.

Lady Hamilton was reported to have visited Honolulu, Tahiti, and Oahu.

[2] The Register of Shipping for 1832 showed Lady Hamilton with Maughan, master, changing to Hayward, T.Ward, owner, and trade London–Southern Fishery.

The whaler L'Aigle reported on 23 May 1832 to Cheviot that Lady Hamilton had been lost in the Mozambique Channel.

Her crew had been saved but her cargo of 1800 barrels of whale oil had been lost.