She was born during the reign of her paternal grandmother Queen Elizabeth II, at which time she was 8th in line to the British throne.

Louise's father, Prince Edward, then Earl of Wessex, was not present for the birth because it occurred suddenly and while he was on an official visit to Mauritius.

[1] Louise was delivered by emergency Caesarean section due to placental abruption, which caused severe blood loss to both child and mother.

[13] In August 2018, Louise accompanied her mother, patron of UK Sail Training, to Haslar Marina in Portsmouth Harbour to meet a group of young girls working towards earning their qualification on an entry-level course of the Royal Yachting Association.

[14] In the same month, mother and daughter attended the final of the Hockey Women's World Cup in London.

[15] To celebrate Louise's 15th birthday in November 2018, mother and daughter made a cameo appearance on Strictly Come Dancing as they watched the popular BBC television show from the audience.

[18][19] Following the death of her grandfather, Prince Philip, Louise accompanied her parents to a church service at the Royal Chapel of All Saints on 11 April 2021.

[29] Louise was taught to ride at an early age, and joined her father on horseback as part of the Queen's 90th birthday celebrations in Windsor in 2016.

[31] In May 2017, she was responsible for leading the carriages of the Champagne Laurent-Perrier Meet of the British Driving Society at the Royal Windsor Horse Show.

[40][41] At birth, Louise automatically became a princess of the United Kingdom due to letters patent issued in 1917 which assigned princely status and the style of Royal Highness to all children of a monarch's sons.