The role has attracted countless notable actresses over the centuries, including Sarah Siddons, Charlotte Melmoth, Helen Faucit, Ellen Terry, Jeanette Nolan, Vivien Leigh, Isuzu Yamada, Simone Signoret, Vivien Merchant, Glenda Jackson, Francesca Annis, Judith Anderson, Judi Dench, Renee O'Connor, Helen McCrory, Keeley Hawes, Alex Kingston, Reshmi Sen, Marion Cotillard, Hannah Taylor-Gordon, Frances McDormand, Tabu, Ruth Negga, Saoirse Ronan and Valene Kane.

[1] Jenijoy La Belle takes a slightly different view in her article, "A Strange Infirmity: Lady Macbeth’s Amenorrhea".

La Belle states that Lady Macbeth does not wish for just a move away from femininity; she is asking the spirits to eliminate the basic biological characteristics of womanhood.

[3] Modern day critic Joanna Levin defines a witch as a woman who succumbs to Satanic force, a lust for the devil, and who, either for this reason or the desire to obtain supernatural powers, invokes (evil) spirits.

[4] Literary scholar Jenijoy La Belle assesses Lady Macbeth's femininity and sexuality as they relate to motherhood as well as witchhood.

[2] She proves herself a defiant, empowered nonconformist, and an explicit threat to a patriarchal system of governance in that, through challenging his masculinity, she manipulates Macbeth into murdering King Duncan.

[5][predatory publisher] Despite the fact that she calls him a coward, Macbeth remains reluctant, until she asks: "What beast was't, then, that made you break this enterprise to me?

In 2010, Gloria Carreño's play "A Season Before The Tragedy of Macbeth" was produced by British Touring Shakespeare and received the plaudits of critics for "its amazing grasp of language".

The dramatist Gloria Carreño describes events from the murder of "Lord Gillecomgain", Gruoch Macduff's first husband, to the fateful letter in the first act of Shakespeare's tragedy.

[citation needed] Marion Cotillard played the character in Justin Kurzel's film adaptation opposite Michael Fassbender as Macbeth.