Lady Mary Pelham first appeared in Lloyd's Register with Hay as master and owner, and trade Falmouth packet.

[3] In 1822, under Anselm Hatch, Lady Mary Pelham carried Irish migrants to New York City.

The Packet Service found the route profitable due to carrying bullion for the Mexican treasury, and mercury to Mexico for processing gold ore.[5] Lady Mary Pelham sailed from Rio de Janeiro on 5 December 1832 direct for Britain.

Lloyd's Register for 1836 showed Lady Mary Pelham with R. Ross, master, the South Australian Company as owner, and with trade London–Australia.

[7] Lady Mary Pelham sailed from South Australia to Hobart to fit-out for a whaling voyage, arriving there 25 September.

She cruised among the Solomon Islands and was reported at Carteret Harbour, New Ireland, where she spoke the US whaler Mechanic.

[15] Lady Mary Pelham was wrecked on 31 August 1849 at Port Fairy, Victoria, or Belfast as it was then officially named.