[1] Lady Shirai was a relative of Nagao Kagetora (the famed Uesugi Kensin).
In 1560, Uesugi Kenshin, a warlord of Echigo province, made large expedition to Kanto region against the Later Hōjō clan.
[2] Lady Shirai would divorce her husband once he turned his back on the Uesugi clan, and serve the 13th Shōgun, Ashikaga Yoshiteru.
At this point, she was over 50 years old, but she was still beautiful, and as she always served in close proximity to Yoshiteru she used the opportunity to talk about Uesugi Kenshin, and build a diplomatic bridge between the two figures.
When Matsunaga Hisahide entered the Yoshiteru's Palace, the Shogun committed suicide, Lady Shirai continues to resist and ends up dying in battle.