The film stars the voices of Tessa Thompson, Justin Theroux, Janelle Monáe, and Sam Elliott with the human characters portrayed by Thomas Mann, Kiersey Clemons, Yvette Nicole Brown, F. Murray Abraham, Adrian Martinez, and Ken Jeong.

The puppy, named Lady, grows up and befriends the neighbors' dogs: elderly Bloodhound Trusty and feisty Scottish Terrier Jacqueline, AKA "Jock".

Two dogs named Peg and Bull discuss Tramp's self-serving nature with Lady, causing her to question why he did not save her from Elliot.

A rat suddenly enters Lulu's nursery, and Lady starts barking frantically, just as Elliot arrives to warn Jim Dear that he has tracked Tramp to their house.

After being released, Lady leads Jim Dear and Darling to the dead rat, then sets out with Jock and Trusty to rescue Tramp.

Outside in the yard, Trusty entertains Dodge and Ollie, two puppies adopted by Jock's owner, with the story of how he helped save "a poor stray with a heart of gold".

[6] On March 19, 2018, it was announced that film was set to be directed by Charlie Bean from a screenplay by Andrew Bujalski with Brigham Taylor serving as a producer.

[7] In July 2018, it was announced that Ashley Jensen, Justin Theroux, and Sam Elliott had been cast in the voice roles of Jock, Tramp, and Trusty, respectively.

[11][12] In September 2018, it was announced that Yvette Nicole Brown and Adrian Martinez had been cast in the live-action roles of Aunt Sarah and the dog-catcher Elliot, respectively.

[23] The song was to be re-written by Nate "Rocket" Wonder, Roman GianArthur, and Monáe due to both its modern-day perceived racist connotations and to fit the characters' depictions in the film.

[27] On November 6, 2019, a featurette which presented each of the dogs chosen to portray the main characters and how they were all rescued from animal shelters and foster homes was released.

The site's critics consensus reads: "Lady and the Tramp's cute dogs and likable cast work well enough, but the live-action update lacks some of the magic that made the original 1955 film such a delight.

[32] In a mixed review, Michael Phillips of the Chicago Tribune wrote, "The worst of this new Lady and the Tramp comes when the script piles on the strenuous comic action, followed by ill-advised dark shadows.