Tzanes has a massive art collection attributed to him nearing over one hundred thirty works.

[1] The Virgin and Child enthroned was a popular theme painted by both Greek and Italian Byzantine painters.

Konstantinos also created a similar version of the Virgin and Child Enthroned in Corfu around 1654.

The painting is part of the Dionysios Loverdos Collection at the Byzantine and Christian Museum.

[2][3] The materials used for the massive icon were egg tempera paint on wood.

The Madonna and Child by Filippo Lippi also features a similar shell-like niche behind the Virgin Mary.

The child holds a banner in his left hand versus the typical scroll prevalent in Cretan paintings.

The artist's color palette for the main figures features red, blue, green, and orange.

Both brothers elevated the Greek style to another level defining the Late Cretan School.