Ladyzhyn (Ukrainian: Ладижин, IPA: [lɐˈdɪʒɪn] ⓘ; Polish: Ładyżyn) is a city in Vinnytsia Oblast, Ukraine.

In the 10th century, Prince Vladimir the Great built fortresses in Ladyzhyn along the river to protect his possessions from the nomadic peoples, such as the Khazars, Pechenegs, and Polovtsians.

The Grand Duchy of Lithuania expanded its territory in the 14th century by annexing principalities in Ukraine, opposed to the Tatars' subjugation of the area.

In 1363, Prince Olgerd, with support of Polish and Ruthenian troops, defeated the Tatar horde, and the cities of Ladyzhyn and Bratslav were burned.

[2] In the 16th century, Ladyzhyn was a wooden fortress city of the Bratslav Voivodeship, surrounded by a thirty-meter dirt rampart.

Doroshenko again asked Turks to help him recapture the city, and Sultan Mehmed IV sent a detachment with his son Oslam Giray.

By a decree of the Presidium of the Supreme Soviet of the Ukrainian SSR of March 21, 1973, Ladyzhyn, in the Trostianets Raion, was classified as a city under district authority.

In 2010, Myronivsky Hliboproduct started construction of the Vinnytsia Broiler poultry farm with a capacity of 400,000 tons of chicken per year and the Ladyzhyn feed mill with a total cost of $750 million, which was scheduled to be completed in 2013–2014.

A bus service regularly carries passengers to the Oblast capital, Vinnytsia, and to other nearby villages and towns.

On April 24, 1998, on the feast of the Life-giving Spring Icon, the construction of the church in honor of St. George the Victorious began.

In 1999, in honor of the Annunciation of the Mother, a chapel was consecrated on August 28, a part of the Ukrainian Orthodox Church in the town.

In 2011, the Catholic community resumed its activities and returned the Church of the Assumption of the Blessed Virgin Mary (Ladyzhyn) [uk] to the town.