Lake City is a town in San Patricio County, Texas, United States.

As of the census[2] of 2000, there were 526 people, 224 households, and 161 families residing in the town.

There were 309 housing units at an average density of 484.3 per square mile (187.0/km2).

25.0% of all households were made up of individuals, and 11.6% had someone living alone who was 65 years of age or older.

The Town of Lake City is served by the Mathis Independent School District.