[1] The town is named after Anne-César, Chevalier de la Luzerne, who guaranteed a personal loan to provide food to American revolutionary troops and who served as a French Minister to the new country.

[10] The town is known for its Adirondack Folk School, with classes designed to keep the arts, crafts and culture of the Adirondacks alive [1], and for the Lake Luzerne Chamber Music Festival where artists such as classical guitarist Joel Brown, the Imani Winds, violinist Raymond Gniewek, saxophonist Erk Rist, jazz greats Chris and Dave Brubeck, and the Philadelphia Orchestra perform during the summer months.

[11] Lake Luzerne is also the home of the Painted Pony Rodeo, the award winning Nettle Meadow Cheese Shop offering Kunik cheese, and the Double "H" Ranch, founded by Charles R. Wood and the actor, Paul Newman.

The ranch provides specialized programs and year-round support for children and their families dealing with life-threatening illnesses.

The Ranch's purpose is to enrich their lives and provide camp experiences that are memorable, exciting, fun, empowering, physically safe and medically sound.

The southern and western town lines are the border of Saratoga County and the Hudson River.

[citation needed] As of the census of 2000, there were 3,219 people, 1,264 households, and 883 families residing in the town.