Lake Monroe is an unincorporated community in Seminole County, Florida, United States.

[2] The Jacksonville, Tampa and Key West Railway (JT&KW) completed a bridge over the St. Johns River just north of Lake Monroe in 1886.

Both the JT&KW and the Orange Belt continued from Monroe Station to Sanford.

A real estate development called St. Joseph's Colony was platted on 640 acres near Monroe Station in 1887.

A German Roman Catholic priest, Felix Prosper Swenbergh, was recruited by Sanford to oversee the colony.