Lake Panasoffkee is a census-designated place (CDP) in Sumter County, Florida, United States.

Boggy Island was an autonomous black Seminole village that was settled by Central African slaves from Kongo.

[5] The Seminoles used the Lake Panasoffkee area to hold councils and Green Corn Dances.

[5] In addition, residents in Sitarkey's Village raised livestock, including cattle, horses, and hogs.

[8] Among the evidence was a group of house foundations and chimneys located in places where there were no known white settlers.

Lake Panasoffkee residents believed that the Wysong Dam contributed to the destruction of the Withlacoochee River.

Two hitchhikers from Illinois discovered the partially decomposed body of an unidentified woman between the ages of 17 and 24 years old under the northbound lane of Lake Panasoffkee's Interstate 75 overpass on February 19, 1971.

[16] In 2012, the Sumter County Sheriff's Department asked the University of South Florida's Tampa Bay Cold Case Project to reexamine the remains of "Little Miss Lake Panasoffkee".

An isotope analysis performed by the project indicated she could have been an immigrant from Greece,[19] possibly hailing from the town of Lavrion (located 60 miles (96 kilometers) southeast of Athens).

[19][21] The new information contradicted the Sumter County Sheriff's Department's initial assumption that the Jane Doe was either white or Native American; they had created composite sketches reflecting those ethnicities.

Sumter County authorities determined, based on the time of her death, that she was visiting the Tarpon Springs area for the celebration of Epiphany on January 6, 1971.

Based on the information from the forensic analysis, the Sumter County Sheriff's Department contacted the Tarpon Springs Police Department and the Greek Orthodox Church about the case and mailed 6,000 flyers to Tarpon Springs businesses and residents.

[17] The Lake Panasoffkee park and preserve protects 9,911 acres (40.11 km2) and offers birdwatching, biking, camping, horseback riding, fishing, hiking and hunting.