The school was originally located on North Florida Avenue and was destroyed by fire in 1927.

It also shares its campus with Lois Cowles Harrison Center for the Visual and Performing Arts.

Harrison students attend academic classes at Lakeland Senior High School.

They were the first of only eight High School bands in the country to have ever won 2 Sudler Flags of Honor.

Over the years the building has housed several different schools including the Lakeland Junior High School, Polk Opportunity Center and Lakeland Middle Academy (renamed the Lawton Chiles Middle Academy in 1999).