Pignotti was a professor in the Faculty of Architecture of the University of Florence and in DAMS of Bologna, where he taught courses on the avant-garde, mass-media and new media.
He creates performances and poetry events involving synesthesia and the senses: poems to eat, to drink, to hear, to sniff, to put in action with gestures and voice.
He creates visual poems;[3][4] these are collage elaborations with writing on images and photography taken from mass media, with the aim of to making evident its contradictions in a playful process similar to those of Pop Art.
[5] His work has been exhibited in many countries and has been written about by critics such as Bruno Mondadori (Storia dell'arte Italiana di Electa).
Other art critics who have been interested in Pignotti's work are Gillo Dorfles, Giulio Carlo Argan, Umberto Eco and Achille Bonito Oliva.