The system consists of a new 10.1-inch portrait screen which also records telemetry, driving data and top speeds.

[8] The engine is mated to the same 7-speed ISR automated manual gearbox[4] as used on an Aventador along with the all-wheel-drive drivetrain developed by Haldex.

The car comes with either leather or Alcantara upholstery on the interior mostly carried over from the Aventador, customizable to the customer's specifications.

[10] The Lamborghini Centenario has a power to weight ratio of 2.18 kg (4.81 lb) per horsepower and a braking distance of 30 m (98 ft) from 100–0 km/h (62–0 mph).

The only change from the coupé counterpart is the weight of the car, which is now set to at least 1,570 kg (3,461 lb) due to the loss of the roof and the addition of chassis reinforcing components.