He was the ninth, and youngest boy, of eleven children born to chemist Lammot du Pont (1831–1884),[2] and his wife, Mary (née Belin) du Pont (1839–1913).

[2] His maternal grandparents were Henry Hedrick Belin and Isabella (née d'Andelot) Belin and his paternal grandparents were Alfred Victor DuPont and Margaretta Elizabeth (née Lammot) DuPont.

His first marriage was on January 27, 1903, to Natalie Driver Wilson (1877–1918),[8] at St. John's P. E. Church and officiated by Bishop Coleman.

[16] Together, they were the parents of one child:[16] Du Pont died on July 24, 1952, in New London, Connecticut of heart disease at age 71.

After Sanger's death, she married Lewis Polk Rutherfurd, who was the widower of Janet Auchincloss Rutherfurd (half-sister of Jackie Kennedy and Lee Radziwill).