The following are listed on the National Register of Historic Places:[7][8] Lancaster is located at 34°43′16″N 80°46′24″W / 34.72111°N 80.77333°W / 34.72111; -80.77333 (34.721100, -80.773315).

As of the 2020 United States census, there were 8,460 people, 3,469 households, and 2,064 families residing in the city.

33.1% of all households were made up of individuals, and 15.2% had someone living alone who was 65 years of age or older.

In 2008 South Carolina Governor Mark Sanford named Andrew Jackson Middle School, located in nearby Kershaw, as the recipient of the state's Best Special Education School Award.

The City is also home to the University of South Carolina at Lancaster, also known as USCL.