[7] As defined by the U.S. Census Bureau, Moncks Corner is included within the Charleston-North Charleston, SC Metropolitan Statistical Area.

[8][9] During the colonial era, Moncks Corner became a major settlement area of French Protestant Huguenots, who came to South Carolina between 1684 and 1688 as refugees due to religious persecution in France.

Moncks Corner was granted the trademark "Capital of Santee Cooper Country" by the South Carolina Secretary of State September 9, 1999, and again October 21, 2004.

The trademark is a symbol of its abundant outdoor activities, such as horseback riding, hiking, water sports, boating and freshwater fishing.

Moncks Corner is also the home of Santee Cooper's corporate office complex.

The Biggin Church Ruins, Cooper River Historic District, Lewisfield Plantation, Mulberry Plantation, Santee Canal, and Strawberry Chapel and Childsbury Town Site are listed on the National Register of Historic Places.

[15] Its boundary extends east to the West Branch of the Cooper River, 3 miles (5 km) south of the outlet of Lake Moultrie.

SC 6 leads northwest from Moncks Corner along the south and west sides of Lakes Moultrie and Marion 39 miles (63 km) to I-95 at Santee.

However, due to the distance from the coast compared to Charleston, it is noticeably hotter in the summer.