From 1946 to 1949 and from 1953 to 1955, they played in the Eastern Professional Basketball League, of which the Red Roses were one of the six original teams.

Von Neida lead the Red Roses to the President's Cup finals, and a big three-game series against the Wilkes-Barre Barons.

Lancaster and Wilkes-Barre met for the inaugural "President's Cup" finals, but there was a dispute over where the games would be played.

The final game of the President's Cup was played on a neutral court, Rockne Hall in Allentown, which the Red Roses lost.

After the 1946-47 season, the Red Roses and the Barons left the EPBL, joining the American Basketball League.