[3][4] By the age of 14, Lopez was playing guitar in the local bars and clubs in the French Quarter, New Orleans, already a professional musician.

[3][6] In December 2000, Lopez and his band made their first touring schedule in Europe, which led to him to supporting both Steve Vai and Jeff Beck the following year.

[3] After the release of Wall of Soul, Lopez performed around Texas, opening shows for Los Lonely Boys and Joe Bonamassa.

[7][8] Over the period between 2008 and 2011, Lopez toured in Europe extensively, playing at larger music festivals and supporting acts including ZZ Top, Whitesnake, Def Leppard, and Rod Stewart.

[4][5] In 2012, Supersonic Blues Machine was formed by Lopez, the drummer Kenny Aronoff, and the bassist and record producer Fabrizio Grossi.

[2][10] They released their debut album, West Of Flushing, South Of Frisco, which was recorded mainly by the three musicians separately and using Pro Tools technology to bring the various elements together.

[11] The band was 'augmented' on the recording by Billy Gibbons, Robben Ford, Walter Trout, Warren Haynes, Eric Gales and Chris Duarte.

Lopez stated "My own personal struggles were overcoming alcoholism, drug addiction and to start eating healthier, lose weight and exercise...

[6] Lopez signed with the Mascot Label Group in November 2017,[12] and his debut album on their Provogue Records imprint was Tell the Truth, which was released on March 2, 2018.