Sangerhausen was a district (Kreis) in the south of Saxony-Anhalt, Germany.

Sangerhausen was merged on July 1, 2007, with Mansfelder Land into the new district Mansfeld-Südharz as part of a reform.

The district was created on October 1, 1816, after Sachsen-Weißenfels became part of Prussia in 1815.

In the communal reform of 1994 the district remained unchanged.

The highest elevation of the district is the Großer Auerberg near Stolberg with 579 m above sea level, the lowest elevation with 119.8 m is near Curtsgehofenmühle southwest of Allstedt.