During the 1990s, U.S. Army Europe underwent a major reorganization, and U.S. hospitals in Frankfurt, Berlin, Nuremberg, and other bases were gradually closed down, or were downsized to clinics.

[9] During the Russian Invasion of Ukraine from 2022, the hospital treated tens of wounded American volunteer veterans who participated in the fighting against Russia.

Roughly half of the American military personnel who died at the hospital from combat injuries from 2005 through 2010 were organ donors.

That was the first year the hospital allowed organs to be donated by military personnel who died there from wounds suffered in Iraq or Afghanistan.

[10] The Landstuhl Regional Medical Center has been awarded the following unit decorations:[11][12] (AGO 1992-06 as 2nd General Hospital)