It is primarily used by Kölner Haie (ice hockey), VfL Gummersbach (handball), Köln RheinStars (basketball), and as a concert venue.

On August 22–23, 2015, the arena hosted ESL One Cologne 2015, one of three major Counter-Strike: Global Offensive tournaments to be held throughout 2015.

[33] On July 7–9, 2017, the arena hosted ESL One Cologne 2017, a Counter-Strike: Global Offensive tournament with a prize pool of $250,000.

On October 8, 2018, the arena hosted an exhibition ice hockey game between Kölner Haie and the Edmonton Oilers, part of the 2018 NHL Global Series Challenge.

On July 5–7, 2019, the arena hosted another edition of the ESL One Cologne, a Counter-Strike: Global Offensive tournament with a prize pool of $300,000.

The venue will host some group phase matches at the FIBA EuroBasket 2022 which the country and Berlin alongside Czech Republic in Prague, Georgia in Tbilisi and Italy in Milan.

The annual Counter-Strike: Global Offensive event, IEM Cologne 2023, returned to the venue on August 4 to 6, 2023, where the prize pool offered was once again $1,000,000, matching that of the previous year's.