In 1549 he purchased the land and castle of Mussomeli, in the Val di Mazara, on which he was invested with the title of count by privilege given on 11 January 1564 by King Philip III of Spain, executed on 27 November, for military services rendered to Charles V by his father.

From this union five children were born including: Lorenzo, 5th Count of Mussomeli († 1660); Giuseppe, 3rd Duke of Camastra († 1708), who was a soldier, deputy of the Kingdom of Sicily (1668), captain of justice (1672) and praetor of Palermo (1679), vicar general of Syracuse, Augusta, and Gela (1676) and of the Val di Noto and Val Demone (1693); Giacomo († 1710), invested with the title of 1st Prince of Lanza by privilege given in 1677; Cesare, knight of the Order of Calatrava, III Prince of Buonfornello since 1684, title acquired by marriage to Anna Bellacera Giglio, widow of Blasco Alliata Galletti, who left no descendants.

[6] Through Giuseppe, who first married Maria Gomez de Silveira Ferreri, the Lanzas acquired by succession in 1675 possession of the Principality of Santo Stefano and the baronies of Pettineo and Migaudo.

He had seven children, born from his second marriage with Orietta Stella Valguarnera of the Dukes of Mirto, of which the eldest son Ignazio, VI Prince of Trabia (1758-1784), governor of the Compagnia della Pace of Palermo ( 1779), who, having died without leaving descendants, was succeeded in the family titles and fiefs by his younger brother Pietro, VII Prince of Trabia (1759-1811), invested in 1789, who was captain of justice of Palermo (1792), secretary of State and court master of the King of Naples and Sicily.

The eldest son Pietro Lanza Branciforte, 9th Prince of Trabia (1807-1855), historian, was magistrate of Palermo (1835, 1837 and 1848) and minister of public works and then of foreign affairs of the provisional government of Sicily (1848-49), died in exile in France.

He was the father of Giuseppe, Prince of Scordia (1889-1927), deputy several times, Ignazio (1890-1917) and Manfredi (1894-1918), the latter lieutenants of the Royal Italian Army in the First World War, in which they obtained the Medal of silver for military valor.

Having obtained no issue from his marriage to the French noblewoman Rose-Blanche Rose Ney d'Elchingen of the Dukes of Elchingen, upon his death all titles passed to members of the cadet branch of the Lanza Princes of Scalea.