Mussomeli (Mussumeli in Sicilian) is a town and comune in the province of Caltanissetta, Sicily, Italy.

Mussomeli is claimed to have been founded in the 14th century by Manfredo III Chiaramonte[3] with the name Manfredi, but later the current name, of Latin or Arab origin, was imposed.

A feast is held every September for the Madonna of the Miracles.

A similar feast is held simultaneously in Buffalo, NY, which has a large number of Mussomeli émigrés and their descendants.

Many townspeople emigrated to the UK, to London and Woking, Surrey where the Madonna dei Miracoli (Madonna of Miracles) is celebrated every July.