Laodice (also spelled Laodike; Greek: Λαοδίκη; died 38 BC) was a princess from the Kingdom of Commagene and a queen of the Parthian Empire by marriage to Orodes II.
Laodice was the first daughter born to King Antiochus I Theos of Commagene and Queen Isias Philostorgos.
In 38 BC Laodice and Orodes with their children, were killed in a parricidal and fratricidal massacre perpetrated by Phraates IV of Parthia to whom Orodes II handed over the Parthian throne after the death of Orodes’ son Pacorus I of Parthia in battle in 38 BC.
The stele depicts a dexiosis relief or a scene between Mithridates II and Laodice shaking hands.
After the Kingdom of Commagene was annexed in 72 by the Roman Emperor Vespasian, her tomb was plundered.