Large-cell lung carcinoma

[2] The clinical presentation of LCLC is nonspecific and can include symptoms such as:[3] LCC is, in effect, a "diagnosis of exclusion", in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer.

[1] The newest revisions of the World Health Organization (WHO) "Histological Typing of Lung Cancer schema" include several variants of LCC, including:[4] One clinically significant subtype is "large-cell neuroendocrine carcinoma" (LCNEC),[5] which is believed to derive from neuroendocrine cells.

[6] In addition, a "subvariant", called "combined large-cell neuroendocrine carcinoma" (or c-LCNEC), is recognized under the new system.

[9] Notable people with the condition include American comedian Andy Kaufman, who died from the disease in 1984.

[citation needed] Treatment often requires a multidisciplinary approach, which will vary based on factors such as the extent of the tumor and the condition and comorbidities of the patient.

Pie chart showing incidence of large-cell lung cancer (shown in green at upper left) as compared to other lung cancer types, with fractions of smokers versus non-smokers shown for each type. [ 7 ]