One classification system for lymphomas divides the diseases according to the size of the white blood cells that have turned cancerous.

[2] Many other B-cell lymphomas feature large cells:[citation needed] Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway.

This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously.

The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.

[citation needed] Less commonly, a large-cell lymphoma may feature T cells.