He played in Major League Baseball (MLB) as an outfielder for the Philadelphia Phillies (1968–71), Minnesota Twins (1973–77), and Milwaukee Brewers (1978–82).

Hisle played his first full season in 1969, when he batted .266 with 20 home runs and finished fourth in NL Rookie of the Year voting.

[2] In a spring training game for the Minnesota Twins on March 6, 1973, Hisle was MLB's first designated hitter; in five at bats, he hit two home runs (one of them a grand slam) and had seven RBIs.

[5] Hisle's best season with the Twins came in 1977, when he hit .302 with 28 home runs and an AL-leading 119 RBIs, as well as being named to his first All-Star Game.

[citation needed] Under his coaching in 1993, Toronto players John Olerud, former Brewers teammate Paul Molitor, and Roberto Alomar finished 1-2-3 in the American League in batting average.