Larry John Loughlin (August 16, 1941 – January 26, 1999) was an American relief pitcher in Major League Baseball who played briefly for the Philadelphia Phillies during the 1967 season.

A star pitcher with the Santa Clara University baseball team, Loughlin played in the 1962 College World Series.

He posted a 15.19 ERA and did not have a decision or saves, giving up nine runs on nine hits and four walks while striking out five in 51⁄1 innings of work.

A double in his only MLB plate appearance left him with a rare career 1.000 batting average.

Following his majors career, Loughlin played in the California Angels and Montreal Expos minor league systems until 1970.