He is known for his work on the TV series Late Night with Conan O'Brien, Ugly Americans, Delocated and Bob's Burgers.

Murphy's subsequent independent live work is a mix of sketch and characters.

He voiced the hostile immigration officer Lt. Francis Grimes on the Comedy Central series Ugly Americans.

Murphy has appeared as a sketch actor on Late Night with Conan O'Brien and has a recurring role as "Jay the Doorman" on the Adult Swim live-action series Delocated.

He has toured with comedian Eugene Mirman and makes an appearance on his 2009 comedy album God is a Twelve-Year-Old Boy With Asperger's, providing the voice of Christopher Walken taking a customer service call.