As a member of the Ohio Senate, Obhof has sponsored and supported legislation on a wide range of issues including education, civil and criminal law, election administration, and taxation.

"[7] The bill requires the study of historically significant documents, including the primary texts of the Declaration of Independence and the United States Constitution, as part of Ohio students' history and government curricula.

[7] Obhof has also passed legislation to modernize Ohio's elections system by using improved technologies such as electronic poll-books; to update Ohio's tax code and save taxpayers millions of dollars by protecting their ability to claim certain credits or deductions; to cut the filing fee for starting a new business by 21%; and to give state law enforcement greater ability to investigate and prosecute money laundering.

In early 2018, Obhof was credited by activists and leaders in both major parties with negotiating a historic, bipartisan reform of Ohio's process for drawing Congressional districts.

[8] The Cleveland Plain Dealer has noted that Obhof is "instrumental in passing key bills" and that he stands out "for notching legislative victories.

[4] He is also responsible for the formal organization of the chamber, including recognizing members in debate, preserving order and decorum, calling for votes and signing all acts.

In 2014, Senator Obhof was named Legislator of the Year by the Public Children Services Association of Ohio, for his work on child protection issues.

Among other reasons, the Bar Association cited Obhof's work on a comprehensive update to the Ohio's general corporation law and its statutes governing LLCs, as well as his support for legal aid and indigent defense.

Obhof is a contributor to The Daily Caller, where he has written about a range of topics including judicial nominations, trade issues, health care and the Second Amendment.