After a panicked attempt to leave town, he transforms into a werewolf and is bludgeoned to death by his father, who does not recognize him, with his own walking stick.
Four years later, Larry is awakened from death when grave robbers open his tomb under a full moon and remove the wolfsbane he was buried with.
Finding that the monster is unable to locate the notes of the recently deceased doctor, Larry seeks out Baroness Elsa Frankenstein, hoping she knows their hiding place.
After the monster carries off Elsa, the Wolf Man attacks him, and the two title characters are swept away by a flood that results when the local tavern owner blows up the town dam to drown the castle's inhabitants.
Things enter a critical stage at night, as Niemann revives the Frankenstein monster and Talbot again turns into a werewolf.
Even though both Dracula and Larry Talbot perished in the previous film, in this entry they are depicted as still alive and seeking a cure for their respective afflictions from a brilliant scientist, Dr. Franz Edelmann.
In the end, Talbot is finally cured of his affliction and falls in love with Edelmann's assistant, Miliza Morrelle (Martha O'Driscoll).
He then kills Edelman, who has been contaminated with Dracula's blood and earlier requested Talbot to end his life if he proved unable to do so himself.
Chick Young (Bud Abbott) and Wilbur Grey (Lou Costello) work as railway baggage-clerks who deliver two crates to McDougal's House of Horrors museum.
The crates contain "the remains of the original Count Dracula" (Bela Lugosi) and "the body of the Frankenstein Monster" (Glenn Strange).
Larry Talbot (Lon Chaney Jr.) has tracked Dracula and the Monster to the area and asks Chick and Wilbur to help him destroy them.
Dracula flees, with the Wolf Man giving chase just as the Monster breaks his restraints and throws Sandra out the window.
In the 2004 film Van Helsing starring Hugh Jackman, Lawrence Talbot is reimagined as a new character named Velkan Valerious (portrayed by Will Kemp).
In the 2010 remake of the film, Lawrence Talbot is played by Puerto Rican actor Benicio del Toro, who was "cast for his resemblance to Lon Chaney Jr., with his clouded, thick features and his air of suffering."
After having his wounds stitched up and being taken back to Talbot Hall, Lawrence goes through an unnaturally fast recovery leading up to the night of the full moon.
The night of the full moon arrives and Lawrence finds his father creeping around Talbot Hall and follows him through the estate to his mother's burial crypt.
Following a brief exchange, the full moon shines and Lawrence painfully transforms into a werewolf and begins his reign of terror among Blackmoor, brutally killing several villagers.
Seconds later, the full moon shines through the asylum window and Lawrence transforms into a werewolf, who brutally murders the doctor and several spectators before escaping.
Several days pass as Gwen tries desperately to find a cure and Lawrence travels back to Blackmoor to settle things once and for all.
Stopped in her tracks by a waterfall, Gwen finds herself cornered by the beast, but instead of killing him with the silver bullet, tries to help him recognize her.
Starting to remember who Gwen is, Lawrence turns back to see that Aberline and his men getting closer and lets out several large howls.
As Gwen sees that Aberline has been bitten, the camera cuts back to the burning Talbot Hall and the Wolfman's howl is heard one last time.