The school was founded in 1973, when Dr. Faustino Legaspi Uy opened a School of Nursing under the Graduate of Nursing (GN) Program at the Las Piñas General Hospital – that eventually became Dr. Faustino L. Uy Medical Foundation – as the clinical division.

Faustino Legaspi Uy's belief that the community would best be served by combining health care and education formed the basis for founding Las Piñas College.

By the 1982–1983 school year, the department of Education, Culture and Sports allowed the institution to offer a two-year Hotel and Restaurant Management course.

[1] The school is currently being run by Centro Escolar University and undergoing significant renovations to date.

Centro Escolar Las Piñas was granted by CHED the permit to offer a Bachelor of Science in Entrepreneurship (BS-ENT) starting in the school year 2018–2019.