The university has academic programs in graduate school, law, the liberal arts, sciences, engineering, nursing, pharmacy, architecture, business administration, and education, as well as secondary, elementary, and preschool.

It is one of the universities in the country to receive an autonomous status by the Commission on Higher Education.

His cousin, Alexander Athos Adamson, came to the country in 1932 to assist him in administering the then-newly founded school, where he served as its vice president, treasurer, and registrar.

Alexander's brother, George Athos Adamson, arrived two years after to serve as a professor and dean of both the school and the College of Engineering.

In 1939, George Lucas' wife, Evdoxia Savaides Adamson, began working at the school, serving as a professor and eventually dean of both Colleges of Education and Liberal Arts and Sciences.

[11] Spanish priest Leandro I. Montañana became the university's second president, holding the office until 1985.

On November 16, 2012, the university inaugurated a museum dedicated to its founders, inside the St. Vincent Building.

In 2013, the university received an ISO 9001:2008 Management Systems certification from TÜV Rheinland.

The university expanded its campus in San Marcelino by acquiring the Meralco building in 1968 and the St. Theresa's College-Manila site just across the street in 1977.

[13] The City Government of Dapitan and Adamson University signed a memorandum of cooperation on September 13, 2023, to establish a new campus in the city, aimed at providing quality education to students in Mindanao; the announcement was posted by the Adamson Chronicle (Autonomous and Official Student Publication of the Adamson University) on their page on September 28, 2023.